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The 30-year fight against HIV
Since its identification as the cause of Aids in 1984, scientists have made major advancements in tackling virus1984 Retrovirus is discovered as cause of Aids and later named human immunodeficiency virus or HIV.1986 Clinical trials show that HIV patients taking AZT (azidothymidine), an antiretroviral drug initially developed as a cancer therapy, were living longer than those who did not. AZT is shown to manage, but not cure, HIV and reduce the rates of mother-to-child infection in pregnancy.1987 The US FDA approves AZT as the first antiretroviral to be used as a treatment for Aids.1995 Jeff Getty, Aids activist, becomes th...
Source: Guardian Unlimited Science - March 3, 2013 Category: Science Authors: Caroline Davies Tags: The Guardian News Health Medical research Aids and HIV Society Source Type: news
Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy
Conclusion: We conclude that an adequately powered clinical trial of IVIG for HIVM would likely require a prolonged recruitment period and multiple participating sites. Lower limb dynamometry is a useful outcome measure for HIVM, which might also be useful in other HIV-related gait disorders.
KEYWORDS: Dynamometry, intravenous immunoglobulin (IVIG), human immunodeficiency virus (HIV), myelopathy
INTRODUCTION
Human immunodeficiency virus (HIV)-associated myelopathy (HIVM) is a rare but well-described neurologic complication of HIV; it was first described early in the acquired immunodeficiency syndrome (AIDS) epidemic, and i...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Demyelinating Disease Movement Disorders Neurodegenerative Disease Neurology Original Research Primary Care Technology Trial Methodology Dynamometry human immunodeficiency virus (HIV) intravenous immu Source Type: research
There Is No Cure for HIV —But Scientists May Be Getting Closer
Cure isn’t a word normally used in the context of AIDS. For most of the 35 years since HIV, the virus responsible for the disease, was first identified, doctors have viewed the notion of a cure as more fantasy than fact.
That’s because HIV is a virus unlike any other. It disables the very immune cells that are supposed to destroy it and also sequesters itself in the body’s cells, staging the ultimate deadly ambush whenever the immune defense’s guard comes down, months or sometimes even years later.
Yet for the first time in the HIV epidemic that currently affects nearly 37 million people worldwide, ...
Source: TIME: Health - March 8, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized AIDS/HIV Source Type: news
A Man May Be Cleared of HIV for the Second Time in History. Here ’s What That Means
A man in London has become only the second person to achieve remission from HIV infection, researchers from the UK reported Tuesday. The therapy responsible has worked on only one other person who is considered to be “cured” of HIV: Timothy Ray Brown, who still does not show signs of the virus in his body after more than 10 years.
Here’s what to know about the landmark case.
How did it happen?
In a letter published in the journal Nature, researchers led by Ravindra Gupta from the University of Cambridge London and Imperial College London and his colleagues say that they used a treatment similar to the one...
Source: TIME: Health - March 5, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized HIV/AIDS Source Type: news
HIV 's efficiency makes it a formidable foe
Although antiretroviral drug therapy suppresses the virus, it cannot get rid of it or end the epidemicAntiretroviral drugs have been an astounding success story, reprieving people with HIV from the brink of death and allowing them to live a full and healthy life. But although the roll-out across the world has saved lives and removed the distressing pictures of wasted Aids victims from our TV screens, experts know the drugs will not end the epidemic. The hunt is on for a cure, but it is proving tough.Antiretroviral drug therapy suppresses the virus to such low levels that people with HIV are no longer infectious, but it can...
Source: Guardian Unlimited Science - March 6, 2014 Category: Science Authors: Sarah Boseley Tags: The Guardian United States World news Health Medical research UK news Aids and HIV Science Society Source Type: news
HIV gene therapy using GM cells hailed a success after trial
Radical treatment helps patients' defences against virus by replacing immune cells with genetically modified versionsA radical gene therapy to combat HIV using genetically modified cells that are resistant to the virus has been declared a success by scientists following the first clinical trial.The treatment, which has never been tested on humans before, raised patients' defences against HIV by replacing some of their natural immune cells with GM versions.Tests on people enrolled in the trial found that the disease-resistant cells multiplied in their bodies.Half of patients were taken off their usual drugs for three months...
Source: Guardian Unlimited Science - March 5, 2014 Category: Science Authors: Ian Sample Tags: The Guardian United States Genetics News Medical research Aids and HIV Science Source Type: news
HIV 's efficiency makes it a formidable foe
Although antiretroviral drug therapy suppresses the virus, it cannot get rid of it or end the epidemicAntiretroviral drugs have been an astounding success story, reprieving people with HIV from the brink of death and allowing them to live a full and healthy life. But although the roll-out across the world has saved lives and removed the distressing pictures of wasted Aids victims from our TV screens, experts know the drugs will not end the epidemic. The hunt is on for a cure, but it is proving tough.Antiretroviral drug therapy suppresses the virus to such low levels that people with HIV are no longer infectious, but it can...
Source: Guardian Unlimited Science - March 6, 2014 Category: Science Authors: Sarah Boseley Tags: Aids and HIV Health Medical research Science United States World news UK news The Guardian Society Source Type: news
Is a Cure for HIV Finally within Reach?
By Esther Tumbare,
Senior global technical director for HIV
A health worker at the San Marcos National Hospital in Guatemala holds an HIV test. Photo by Levi Dieguez for IntraHealth International.July 26, 2022Despite huge strides and years of methodical research, efforts to find a simple, easily scalable HIV cure have evaded the scientific world. An HIV cure includes both remission and eradication and needs to be accessible to the millions of people living with HIV, most of them in Africa.Today we are closer to a cure than we’ve ever been before.In 2008, the first cure in an HIV-infected patient was announced. Du...
Source: IntraHealth International - July 26, 2022 Category: International Medicine & Public Health Authors: kseaton Tags: HIV & AIDS Source Type: news
Global HIV/AIDS Fight Is At a Crossroads After COVID-19 Setbacks
Hard-won progress against HIV has stalled, putting millions of lives at risk, according to an alarming report Wednesday on how the COVID-19 pandemic and other global crises are jeopardizing efforts to end AIDS.
Worldwide, the years-long decline in new HIV infections is leveling off. Worse, cases began climbing in parts of Asia and the Pacific where they previously had been falling, according to the United Nations agency leading the global AIDS fight.
The number of people on lifesaving HIV treatments grew more slowly last year than it has in a decade. Inequities are widening. Every two minutes last year, a teen girl or youn...
Source: TIME: Health - July 28, 2022 Category: Consumer Health News Authors: Lauran Neergaard/AP Tags: Uncategorized healthscienceclimate HIV/AIDS Public Health wire Source Type: news
Quarter Century of Anti-HIV CAR T Cells
AbstractPurpose of ReviewA therapy that might cure HIV is a very important goal for the 30 –40 million people living with HIV. Chimeric antigen receptor T cells have recently had remarkable success against certain leukemias, and there are reasons to believe they could be successful for HIV. This manuscript summarizes the published research on HIV CAR T cells and reviews the current anti -HIV chimeric antigen receptor strategies.Recent FindingsResearch on anti-HIV chimeric antigen receptor T cells has been going on for at least the last 25 years. First- and second-generation anti-HIV chimeric antigen receptors have been...
Source: Current HIV/AIDS Reports - March 3, 2018 Category: Infectious Diseases Source Type: research
Africa: First Case of HIV Cure in a Woman After Stem Cell Transplantation Reported At CROI-2022
[WHO] The International Maternal Pediatric Adolescent AIDS Clinical Trial Network (IMPAACT) P1107 reported the first case of HIV cure in a woman living with HIV submitted to a dual stem cell transplant (i.e., an umbilical cord blood transplant combined with a half-matched bone marrow transplant) for treatment of an acute myelogenous leukemia. The IMPAACT P1107 researchers presented the case details during the oral abstract session held at the 29th Conference on Retroviruses and Opportunistic Infections (CROI 202
Source: AllAfrica News: HIV-Aids and STDs - April 4, 2022 Category: Infectious Diseases Source Type: news
Oldest Patient Yet Cured of HIV After Stem Cell Transplant Oldest Patient Yet Cured of HIV After Stem Cell Transplant
The oldest patient yet has been cured of HIV after receiving a stem cell transplant for leukemia, researchers reported on Wednesday.Reuters Health Information
Source: Medscape Transplantation Headlines - July 28, 2022 Category: Transplant Surgery Tags: HIV/AIDS News Source Type: news
Translationally Controlled Tumor Protein-Mediated Stabilization of Host Antiapoptotic Protein MCL-1 Is Critical for Establishment of Infection by Intramacrophage Parasite < em > Leishmania donovani < /em >
J Immunol. 2022 May 13:ji2100748. doi: 10.4049/jimmunol.2100748. Online ahead of print.ABSTRACTIn the early phase of infection, the intramacrophage pathogen Leishmania donovani protects its niche with the help of the antiapoptotic protein myeloid cell leukemia-1 (MCL-1). Whether Leishmania could exploit MCL-1, an extremely labile protein, at the late phase is still unclear. A steady translational level of MCL-1 observed up to 48 h postinfection and increased caspase-3 activity in MCL-1-silenced infected macrophages documented its importance in the late hours of infection. The transcript level of MCL-1 showed a sharp declin...
Source: Journal of Immunology - May 13, 2022 Category: Allergy & Immunology Authors: Jayeeta Giri Moumita Basu Shalini Roy Tarun Mishra Kuladip Jana Ajit Chande Anindita Ukil Source Type: research
